In the last decade, RDW and MPV have both been considered new biomarkers for the prognosis of cardiovascular disease. Increased MPV is commonly seen in primary thrombocytopenic purpura and myelodysplastic syndrome, while decreased MPV is commonly seen in acute leukemia chemotherapy and aplastic anemia. Mean platelet volume (MPV) is a common indicator of platelet activity in routine blood. Elevated RDW is commonly seen in iron deficiency anemia, megaloblastic anemia, etc. In previous studies, RDW has been used for the diagnosis and differential diagnosis of erythrocyte disorders, especially anemia, and for the evaluation of nutritional status. It is calculated as the standard deviation (SD) of the distribution of red blood cell volume divided by the mean corpuscular volume (MCV) and then multiplied by 100. Red blood cell distribution width (RDW) is a common indicator in blood routine analysis, which reflects the heterogeneity of red blood cell volume in the circulation.
Preoperative baseline RDW and postoperative RDW levels can preliminarily predict the effect of different metabolic surgeries in patients with obesity and DM/IGR. No significant difference in weight index was found in the high and low levels of the MPV before surgery in either group at other follow-up time points. %BW and change in BW and BMI (ΔBW and ΔBMI) at 6 and 12 months after surgery in the high-level RDW (≥ 12.90) before surgery were significantly higher than those in the low level in the RYGB group. In the RYGB group, the RDW level of patients in the high-level percentage weight loss (%BW) (≥ 31.90) at 6 and 12 months after surgery decreased significantly compared to those in the corresponding low level. Twelve months after surgery, the RDW level in the RYGB group was significantly lower than that before surgery. Levels of RDW and MPV in both groups were significantly higher than before 1 month after surgery and then gradually decreased. We retrospectively analyzed the body weight (BW), body mass index (BMI) and blood routine index of 98 patients with obesity and DM/IGR who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). This study aimed to observe the predictive values of RDW and MPV for weight loss after different metabolic surgeries in patients with obesity and abnormal glucose metabolism.
Addition of MPV to the platelet count allows subtler disorders to be detected (when the platelet count is normal), and allows distinction of the cause of thrombocytopenia.Red blood cell distribution width (RDW) and mean platelet volume (MPV) are both new biomarkers for the prognosis of many diseases. High MPV thus appears correlated with myeloproliferative disease or thalassemia and low MPV, with cytotoxic drugs or marrow hypoplasia. All had sepsis, splenomegaly, aplastic anemia, chronic renal failure, or a disease being treated with myelosuppressive drugs.
52 patients had an MPV that was inappropriately low for the platelet count (high, normal, or low). Seven patients had high MPV and high platelet count: causes included myeloproliferative disorders, inflammation, iron deficiency, and splenectomy, 25 patients had high platelet counts and normal MPV: the causes were inflammation, infection, sickle cell anemia, iron deficiency, or chronic myelogenous leukemia. 15 patients had high MPV and normal platelet count: 12 had heterozygous thalassemia, and three had iron deficiency. 11 patients had high MPV and low platelet count: all had hyperdestructive causes. Addition of a second variable, mean platelet volume (MPV), to the routine blood count allows classification of patients into 9 categories: high, low, or normal MPV, and high, low or normal platelet count.
Classification of platelet disorders has been based on the platelet count.
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